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Saturday, July 17, 2021

Delta ‘fastest and fittest’ of COVID variants

Article by Andrea King



COVID Variants (GP)

The Delta variant of COVID-19 will definitely accelerate the pandemic.

This is the view of Yale Medicine epidemiologist Dr F. Perry Wilson, who said the uniqueness of this strain of the virus is how quickly it is spreading.

The first Delta case was discovered in India in December 2020, and quickly became the dominant strain there and in Great Britain. The Centre for Disease Control and Prevention (CDC) estimates that by the end of June, more than 20 per cent of the cases in the USA were of that strain. Medical experts agree that the Delta strain is more contagious than the other virus strains.

In mid-June, the CDC labelled Delta as “a variant of concern,” using a designation also given to the Alpha strain that first appeared in Great Britain, the Beta strain that first surfaced in South Africa, the two Epsilon variants first diagnosed in the US, and the Gamma strain identified in Brazil, writes Kathy Katella.

The new naming conventions for the variants were established by the World Health Organisation (WHO) at the beginning of June as an alternative to numerical names.

According to yalemedicine.org, the World Health Organisation called this version of the virus “the fastest and fittest”.

“It’s actually quite dramatic how the growth rate will change,” says Dr Wilson. Delta is spreading 50 per cent faster than Alpha, which was 50 per cent more contagious than the original strain of SARS-CoV-2, he told yalemedicne.org.

“In a completely unmitigated environment – where no one is vaccinated or wearing masks – it’s estimated that the average person infected with the original coronavirus strain will infect 2.5 other people,” Dr Wilson says. “In the same environment, Delta would spread from one person to maybe 3.5 or other people.”

People who have not been fully vaccinated against COVID-19 are most at risk, especially young people.

“As older age groups get vaccinated, those who are younger and unvaccinated will be at higher risk of getting COVID-19 with any variant,” says Dr Yildirim, Yale Medicine paediatric infectious diseases specialist and a vaccinologist. “But Delta seems to be impacting younger age groups more than previous variants.”

Even as the Delta strain has been present for seven months, there is still much to learn about it. Research is ongoing into whether people will be more ill than with the original virus.

Katella states there have been reports of symptoms that are different than those associated with the original coronavirus strain. It is also unclear if the Delta strain could cause more infections in people who were vaccinated or have natural immunity from a prior COVID-19 infection.

It is also too soon to know whether a booster modified to target the Delta variant will be needed. Experts also do not yet know if vaccinated people will need an additional shot at some point to boost the overall immunity they got from their first shots.

“It seems like cough and loss of smell are less common symptoms. And headache, sore throat, runny nose, and fever are present based on the most recent surveys in the UK, where more than 90 per cent of the cases are due to the Delta strain,” Dr Yildirim says, adding the risk of infection is significantly lower than in someone who has not been vaccinated.

Doctors advise that vaccination is the best protection against the Delta variant of COVID-19.

“Like everything in life, this is an ongoing risk assessment,” Dr Yildirim said. “If you are in a crowded gathering, potentially with unvaccinated people, you put your mask on and keep social distancing. If you are unvaccinated and eligible for the vaccine, the best thing you can do is to get vaccinated.”

“From what we know so far, people who are fully vaccinated against the coronavirus appear to have protection against Delta, but anyone who is unvaccinated and not practising preventive strategies is at risk for infection by the new variant,” Dr Wilson added.  (AK)


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SARS-CoV-2 variants of concern as of 15 July 2021

Variants of concern (VOC)

For these variants, clear evidence is available indicating a significant impact on transmissibility, severity and/or immunity that is likely to have an impact on the epidemiological situation in the EU/EEA. The combined genomic, epidemiological, and in-vitro evidence for these properties invokes at least moderate confidence. In addition, all the criteria for variants of interest and under monitoring outlined below apply.



Variants of interest (VOI)

For these variants, evidence is available on genomic properties, epidemiological evidence or in-vitro evidence that could imply a significant impact on transmissibility, severity and/or immunity, realistically having an impact on the epidemiological situation in the EU/EEA. However, the evidence is still preliminary or is associated with major uncertainty. In addition, all the criteria for variants under monitoring outlined below apply.


Variants under monitoring

These additional variants of SARS-CoV-2 have been detected as signals through epidemic intelligence, rules-based genomic variant screening, or preliminary scientific evidence. There is some indication that they could have properties similar to those of a VOC, but the evidence is weak or has not yet been assessed by ECDC. Variants listed here must be present in at least one outbreak, detected in a community within the EU/EEA, or there must be evidence that there is community transmission of the variant elsewhere in the world.

Friday, July 2, 2021

DELTA Variant COVID and Why It's Concerning!

Doctor Mike Hansen, MD

Internal Medicine | Pulmonary Disease | Critical Care Medicine
21 Jun 2021

DELTA Variant COVID and Why It's Concerning!

  • Is it more contagious?
  • Will the vaccines work against it?
  • Is it a deadlier disease with worse symptoms?
In a study done in Scotland, which was published in The Lancet, researchers showed that the risk of being hospitalized with the COVID Delta variant is double that of the alpha variant. The covid delta variant has recently made its way to the US, constituting 10% of COVID cases. However, that figure is doubling every two weeks, and it's only a matter of time before it becomes the dominant strain. It makes up about 25% of Colorado, Montana, North Dakota, South Dakota, Utah, and Wyoming in the Midwest. In a study done in the UK from May 20 to Jun 7th, the researchers, led by Steven Riley, looked at their data, which suggest that the covid delta variant is about 60% more transmissible than the alpha, which was the variant first identified in the UK, which was more contagious than the original strain that originally emerged from Wuhan. Furthermore, they showed a doubling time of 11 days with the delta variant and an estimated R (reproductive) number of 1.44. And those younger than age 50 were 2.5 times more likely to be infected than older people. The data showed that the covid Delta variant's affinity for the ACE2 receptor was slightly better than the original Wuhan strain. One of the delta’s mutations in its RBD is what allows for this. The virus uses its spike protein to bind to the ACE2 receptor in the body. It’s the key in the lock analogy. The virus then fuses with the cell membrane. This process relies on cleavage. Meaning enzymes on the cell membrane cut the spike protein at two different sites, triggering the cell to engulf the virus. A second delta mutation is in one of these cleavage sites. Better cleavage, better reproduction. Another takeaway from this study is that the authors concluded that the neutralization of both viruses is reduced compared with the original Wuhan strains. Still, there is no evidence of widespread antibody escape. However, they said the data did suggest that those previously infected with COVID may be more susceptible to reinfection by the new delta variant. Also, it looks like monoclonal antibody treatments are ineffective at treating the delta variant. The big concern is “vaccine escape,” meaning that the current vaccines will become far less effective as the virus evolved. So far, it hasn’t happened, but eventually, we will need new covid vaccines for the variants, likely a yearly thing. The good news? Covid Vaccines are still protective against the Delta variant. According to research released by Public Health England: For the Pfizer vaccine, after both doses, it was 88% effective in preventing symptomatic disease, 96% effective at preventing hospitalization. The Oxford/AstraZeneca vaccine was 92% effective at preventing hospitalization if they had both shots. If you only get one shot of either of these covid vaccines, the effectiveness is pretty low, around 30-40%. More studies will soon be available when it comes to the Moderna and Johnson & Johnson vaccines.

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